The advisory committee and the administrator should consider the following design criteria: (1) Allowing the use of federal Health Insurance Portability and Accountability Act of 1996 compliant, government level secured cloud computing resources to save funding; (2) Ensuring all inbound data is converted to a common standard and ensuring that data quality checks are done on inbound data; (3) Requiring all communications to and from the database to use encryption and IP whitelisting where appropriate; (4) Providing industry standard interfaces for accessing the data from approved users; (5) Grouping the data in ways to match the relevant cohorts of interest; and (6) Insuring that at no point does any personally identifiable information reside in the database.